Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population
Clinical Psychopharmacology and Neuroscience
;
: 250-255, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-108199
ABSTRACT
OBJECTIVE:
Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis.METHODS:
We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (−759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system.RESULTS:
We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group.CONCLUSION:
This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sérotonine
/
Facteurs de risque
/
Régions promotrices (génétique)
/
Céphalées
/
Polymorphisme de nucléotide simple
/
Récepteur de la sérotonine de type 5-HT2C
/
Allèles
/
Études d'associations génétiques
/
Volontaires sains
/
Céphalée
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Clinical Psychopharmacology and Neuroscience
Année:
2016
Type:
Article
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