Age and prognosis of papillary thyroid carcinoma: retrospective stratification into three groups / 대한외과학회지
Journal of the Korean Surgical Society
;
: 259-266, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-10844
ABSTRACT
PURPOSE:
We investigated the prognosis according to age in papillary thyroid carcinoma (PTC) patients.METHODS:
We retrospectively evaluated 2,890 patients who underwent thyroidectomy due to PTC between May 2004 and Aug 2008. We divided patients into 3 groups young ( or =55 years old).RESULTS:
Median age was 47.0 years old (range, 15 to 82 years). Within a follow-up period median of 50 months, there were 148 (5.1%) locoregional recurrences, 6 (0.2%) PTC-related deaths, and 18 (0.6%) PTC-unrelated deaths. Outcomes were more favorable in the young group, with no PTC-related death despite the frequent locoregional recurrence. In the old group compared to the middle, there was a higher proportion of male, and more aggressive types as T3 or N1b, higher mean tumor number, more multiplicity, and bilaterality. The old group of > or =55 years did not show a significant difference in PTC-related deaths than other age groups in Cox analysis (OR, 0.9; P = 0.677), but a significant cutoff age in PTC-related deaths at 62.5 years was determined in ROC analysis (area under curve = 0.912).CONCLUSION:
We showed that the or =62.5 years group shows a poor prognosis regardless of other factors such as male sex or tumor aggressiveness. Further multiinstitutional studies are needed to elucidate the prognosis according to patient's age.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Récidive
/
Glande thyroide
/
Thyroïdectomie
/
Facteur IX
/
Tumeurs de la thyroïde
/
Carcinomes
/
Études rétrospectives
/
Courbe ROC
/
Études de suivi
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Journal of the Korean Surgical Society
Année:
2012
Type:
Article
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