Usefulness of Measurement of Serum Iodine Level to Assess the Appropriate Low Iodine Diet Preparation / 대한갑상선학회지
Journal of Korean Thyroid Association
;
: 143-147, 2012.
Article
Dans Coréen
| WPRIM
| ID: wpr-10848
ABSTRACT
BACKGROUND AND OBJECTIVES:
Low-iodine diet (LID) is generally recommended prior to radioactive iodine (RAI) therapy to increase RAI uptake. Recently, we suggested spot urine iodine/creatinine (I/Cr) ratio as a good alternative method replacing measurement of 24 hr urine iodine excretion for the evaluation of appropriate LID preparation. In next step, we studied to evaluate the usefulness of serum iodine concentration comparing with urine iodine concentration and urine I/Cr ratio to assess LID preparation status. MATERIALS ANDMETHODS:
We prospectively measured serum iodine concentration, spot urine iodine concentration, and urine I/Cr ratio in 419 patients with differentiated thyroid carcinoma undergoing LID. Appropriate LID preparation was defined as urine I/Cr ratio less than 66.2 ug/gCr.RESULTS:
There were significant correlations between serum iodine and the spot urine iodine concentrations or urine I/Cr ratio; the correlation coefficient was 0.51 for urine iodine concentration and 0.62 for I/Cr ratio (p<0.001). Calculated R2 after log-log transformation was 0.45 for I/Cr ratio. The cutoff value of serum iodine concentration was 20.4 ug/L (sensitivity 79.3%, specificity 81.5%) for the evaluation of appropriate LID.CONCLUSION:
Measurement of serum iodine concentration may be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively low compared to the urine I/Cr ratio.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de la thyroïde
/
Études prospectives
/
Sensibilité et spécificité
/
Régime alimentaire
/
Iode
Type d'étude:
Etude diagnostique
/
Étude observationnelle
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of Korean Thyroid Association
Année:
2012
Type:
Article
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