Effects of Galantamine Treatment on Attention, Activities of Daily Living, and Neuropsychiatric Symptoms between the Patients with Pure Alzheimer's Disease and Mixed Dementia
Journal of Korean Geriatric Psychiatry
; : 24-30, 2012.
Article
de Ko
| WPRIM
| ID: wpr-108767
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVES: The purpose of this study was to compare the efficacy of galantamine treatment, especially attention ability between patients with pure Alzheimer's disease (AD) and Mixed dementia (MD) during a 24-week trial. METHODS: A total of 40 patients were recruited for this 24-week study. The effect of galantamine on attention was measured using Seoul Computerized NeuroCognitive Function Test (SCNT) and frontal functions test of Seoul Neuropsychological Screening Battery (SNSB). Patients'activities of daily living using the Seoul-Activities of Daily Living (S-ADL) and the Seoul-Instrumental Activities of Daily Living (S-IADL) ; behavioral symptoms using the Korean version Neuropsychiatric Inventory (K-NPI) were measured at baseline and 24-week. RESULTS: 17 pure AD patients and 23 MD patients were analyzed in this study. Attention as measured by SCNT was not significantly different from baseline after 24 weeks of treatment in both groups. There was no significant difference between two groups in mean change from baseline in the SCNT, S-ADL, S-IADL and K-NPI scores at 24-week. CONCLUSION: Galantamine showed a therapeutic effect on cognition, activities of daily living, neuropsychiatric symptoms in pure AD and MD. Furthermore, Galantamine may specifically help to maintain attention and it may have positive effects on other cognitive and functional abilities.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Attention
/
Symptômes comportementaux
/
Activités de la vie quotidienne
/
Dépistage de masse
/
Cognition
/
Démence
/
Maladie d'Alzheimer
/
Galantamine
Type d'étude:
Diagnostic_studies
/
Screening_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Journal of Korean Geriatric Psychiatry
Année:
2012
Type:
Article