Physiological spaces and multicompartmental pharmacokinetic models
Translational and Clinical Pharmacology
;
: 38-41, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-108802
ABSTRACT
The idea of body compartments has its origins in physiology and antedates their use in both physiologically-based predictive pharmacokinetic models and in the simpler compartmental models used to analyze pharmacokinetic data. Whereas physiologically-based pharmacokinetics has evolved to use increasingly sophisticated organ-based models, most compartmental models for data analysis are used without regard for their underlying physiological basis. However, detailed analysis of inulin and urea kinetics has offered some understanding of the physiological basis underlying some three-compartment pharmacokinetic models. In addition, these simple models have yielded new insight into physiological phenomena.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Urée
/
Pharmacocinétique
/
Cinétique
/
Statistiques comme sujet
/
Phénomènes physiologiques
/
Inuline
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Translational and Clinical Pharmacology
Année:
2015
Type:
Article
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