Results of treatment of marrow failure by cyclosporine in Cho Ray Hospital during 1995-1999

ABSTRACT

After 2 months, more patients in the cyclosporine group had a complete or partial remission in response to the treatment than did patients in the prednison group (53,85% and 7,69%; P0,05. Hb concentration > 90g/l is 81,8% granulocyte counts >1,56G/l is 72,72%, platelet counts >100G/l is only 36,36%. 2 patients with responses in the cyclosponrine group relapsed after 24 months of treatment. Survival rate of patients in the cyclosporine group is 15/16 (93,57%) and in the prednison group is 6/15 (40%), P<0,05. Conclusion: Immunosuppressive treatment of aplastic anemia with cyclosponrine appears to be more effective than prednison and may represents a treatment of choice for patients with idiopathic aplastic anemia who are not eligible for bone marrow transplantation.