The immunosuppression effect of cyclosporine A on the allogenic calvarial bone graft in mice
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 353-359, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-109512
ABSTRACT
INTRODUCTION:
This study examined the effect of cyclosporine A (CsA) on the allogenic cranial bone graft in the mice. MATERIALS ANDMETHODS:
Twenty eight 12-week-old male ICR mice weighing 40 g were used. The experimental group was injected subcutaneously with CsA (10 mg/kg/day) diluted in Caster oil for 7 days prior to the graft until sacrifice. The control group was injected with the same solution without CsA.RESULTS:
In the experimental group, fibrous connective tissues and small amounts of inflammatory cells were observed. At 2 weeks after the allograft in the experimental group, new bone formation in fibrous collagenous tissue and around the allogenic bone was noted. At 4 weeks after the allograft, new bone formation was active along and at the periphery of the mature allogenic bone. The proliferation of blood vessels increased in bone marrow. In the control group, fibrous tissues and inflammatory cells were observed around the allogenic bone and existing bone at 1 week. At 2 weeks after the allograft, the proliferation of blood vessels accompanied by inflammatory cells were scattered in the fibrous connective tissues. New bone formation around the allogenic and existing bone could be observed. At 4 weeks after the allograft, inflammatory cells were severely infiltrated around the allogenic bone. Osteoclasts were scattered along the allogenic bone and induced bone resorption.CONCLUSION:
These results suggest that the daily administration of CsA (10 mg/kg/day) induces efficient immunosuppression without serious complications ,and this protocol might be useful for the experimental model of allogenic bone grafts.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéoclastes
/
Ostéogenèse
/
Transplantation homologue
/
Vaisseaux sanguins
/
Moelle osseuse
/
Collagène
/
Immunosuppression thérapeutique
/
Ciclosporine
/
Tissu conjonctif
/
Transplants
Limites du sujet:
Animaux
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Année:
2010
Type:
Article
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