Focused Update on Primary Stroke Prevention in Patients with Atrial Fibrillation in Korean Clinical Practice Guidelines for Stroke / 대한뇌졸중학회지
Korean Journal of Stroke
;
: 106-115, 2012.
Article
Dans Coréen
| WPRIM
| ID: wpr-109665
ABSTRACT
Pivotal clinical trials testing the efficacy of new antithrombotics for the prevention of stroke and systemic embolism in patients with atrial fibrillation have been published since the release of the first edition of Korean clinical practice guidelines for primary stroke prevention. From July 2007 to August 2012, 5 clinical studies and update of guidelines in Europe and North America were identified through systematic search. In patients with atrial fibrillation who were unsuitable for warfarin, the combination of clopidogrel and aspirin reduced the risk of stroke at the cost of increased major bleedings as compared to aspirin. In patients with nonvalvular atrial fibrillation and risk factors for stroke, new oral anticoagulants, dabigatran, rivaroxaban and apixaban, were as effective as or more effective than warfarin in preventing stroke or systemic embolism. The risks of major bleeding with novel anticoagulants were similar to or lower than that of warfarin. Particularly, the risk of intracranial bleeding was significantly lower with novel anticoagulants than with warfarin. In this report, we summarized the new evidences and updated our recommendations for primary stroke prevention in patients with atrial fibrillation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prévention primaire
/
Pyrazoles
/
Pyridones
/
Fibrillation auriculaire
/
Thiophènes
/
Warfarine
/
Benzimidazoles
/
Ticlopidine
/
Acide acétylsalicylique
/
Morpholines
Type d'étude:
Etude d'étiologie
/
Guide de pratique
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
Pays comme sujet:
Amérique du Nord
/
Europe
langue:
Coréen
Texte intégral:
Korean Journal of Stroke
Année:
2012
Type:
Article
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