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APOA5 Polymorphism Is Associated with Metabolic Syndrome in Korean Postmenopausal Women
Endocrinology and Metabolism ; : 276-281, 2012.
Article Dans Coréen | WPRIM | ID: wpr-110113
ABSTRACT

BACKGROUND:

Menopause is an independent risk factor in metabolic syndrome which induced an alteration of the lipid metabolism by hormonal changes. Apolipoprotein A5 gene (APOA5) was related to the regulation of triglyceride and high density lipoprotein cholesterol (HDL-C) level with biosynthesis and decomposition. This study was conducted to investigate the relationship between APOA5 polymorphism and metabolic syndrome in Korean postmenopausal women.

METHODS:

This study included 307 postmenopausal women with anthropometric and biochemical measurement in 2010-2011. The polymorphism of APOA5 was analyzed by polymerase chain reaction-restriction fragment length polymorphism method with MseI restriction enzyme.

RESULTS:

The metabolic syndrome prevalence with TT genotype was significantly lower than the frequency in those with TC/CC (27.09%, 38.46%, and 45.71% for TT, TC, and CC, respectively; P < 0.05). Multiple regression analysis of metabolic syndrome risk factors indicated that postmenopausal women with CC genotype had a higher risk with 3 times than that in TT genotype (P < 0.05). APOA5 C carriers showed an increased risk of triglyceride level (odd ratio, 2.93 and 1.85 for CC and TC+CC, respectively; P < 0.05). Interestingly, HDL-C was related to triglyceride directly in comparison to APOA5.

CONCLUSION:

The results of this study indicate that APOA5 has an influence on serum triglyceride and HDL-C, which contribute to metabolic syndrome in Korean postmenopausal women.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Apolipoprotéines / Apolipoprotéines A / Triglycéride / Ménopause / Cholestérol / Prévalence / Facteurs de risque / Polymorphisme de nucléotide simple / Syndrome métabolique X / Métabolisme lipidique Type d'étude: Etude d'étiologie / Étude de prévalence / Facteurs de risque Limites du sujet: Femelle / Humains langue: Coréen Texte intégral: Endocrinology and Metabolism Année: 2012 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Apolipoprotéines / Apolipoprotéines A / Triglycéride / Ménopause / Cholestérol / Prévalence / Facteurs de risque / Polymorphisme de nucléotide simple / Syndrome métabolique X / Métabolisme lipidique Type d'étude: Etude d'étiologie / Étude de prévalence / Facteurs de risque Limites du sujet: Femelle / Humains langue: Coréen Texte intégral: Endocrinology and Metabolism Année: 2012 Type: Article