Efficacy and Safety of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Hepatocellular Carcinomas Compared with Radiofrequency Ablation Alone: A Time-to-Event Meta-Analysis
Korean Journal of Radiology
;
: 93-102, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-110208
ABSTRACT
OBJECTIVE:
To compare the efficacy and safety of combined radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) with RFA alone for hepatocellular carcinomas (HCC). MATERIALS ANDMETHODS:
Randomized controlled trial (RCT) studies that compared the clinical or oncologic outcomes of combination therapy of TACE and RFA versus RFA for the treatment of HCC were identified through literature searches of electronic databases (Pubmed, Embase, Cochrane Library, China Biology Medicine disc, China National Knowledge Infrastructure, and Google Scholar). Hazard ratios (HRs) or odds ratios (ORs) with their corresponding 95% confidence interval (CI) were combined as the effective value to assess the summary effects. The strength of evidence was rated by the Grading of Recommendations Assessment, Development, and Evaluation system.RESULTS:
Six RCTs with 534 patients were eligible for inclusion in this meta-analysis. The meta-analysis showed that the combination of TACE and RFA is associated with a significantly longer overall survival (HR = 0.62, 95% CI 0.49-0.78, p < 0.001) and recurrence-free survival (HR = 0.55, 95% CI 0.40-0.76, p < 0.001) in contrast with RFA monotherapy. The seemingly higher incidence of major complications in the combination group compared with RFA group did not reach statistical significance (OR = 1.17, 95% CI 0.39-3.55, p = 0.78).CONCLUSION:
In patients with HCC, the combination of TACE and RFA is associated with significantly higher overall survival and recurrence-free survival, as compared with RFA monotherapy, without significant difference in major complications.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Odds ratio
/
Modèles des risques proportionnels
/
Chine
/
Résultat thérapeutique
/
Chimioembolisation thérapeutique
/
Ablation par cathéter
/
Association thérapeutique
/
Carcinome hépatocellulaire
/
Survie sans rechute
/
Tumeurs du foie
Type d'étude:
Essai clinique contrôlé
/
Etude d'étiologie
/
Guide de pratique
/
Revues systématiques évaluées
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Korean Journal of Radiology
Année:
2016
Type:
Article
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