A Pilot Randomized Clinical Study of the Additive Treatment Effect of Photodynamic Therapy in Breast Cancer Patients with Chest Wall Recurrence / 한국유방암학회지
Journal of Breast Cancer
;
: 161-166, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-110219
ABSTRACT
PURPOSE:
This study investigated the additive effect of photodynamic therapy (PDT) plus traditional radiotherapy (RT) for patients with breast cancer and chest wall recurrence.METHODS:
A total of 40 patients with recurrent breast cancer were prospectively randomized to receive RT alone (group A, n=20) or PDT and RT in combination (group B, n=20). Traditional RT at a dose of 50 Gy was delivered in 25 fractions with or without exposure to 5-aminolevulinic acid and red light as PDT.RESULTS:
The response rates were not statistically different between the groups, but more patients achieved a complete response (CR) in group B (50%) than in group A (20%). The median time to CR in group B was significantly shorter than that in group A (109.6 days vs. 175.2 days, p=0.001). Adverse event profiles were not different between the groups.CONCLUSION:
An additive antitumor effect is demonstrated with additional PDT to RT. This combination therapy might reduce the duration of exposure to RT, but further investigation is warranted.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Photothérapie dynamique
/
Radiothérapie
/
Récidive
/
Tumeurs du sein
/
Études prospectives
/
Paroi thoracique
Type d'étude:
Essai clinique contrôlé
/
Étude observationnelle
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Breast Cancer
Année:
2014
Type:
Article
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