Glycopeptide and Aminoglycoside Resistance of Vancomycin-resistant Enterococcus faecium in Korea / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
;
: 18-22, 2003.
Article
Dans Coréen
| WPRIM
| ID: wpr-110700
ABSTRACT
BACKGROUND:
Nosocomial infections caused by vancomycin-resistant enterococci (VRE) are increasing problem in Korea. Until now, no nationwide study has been performed. The aim of the present study was to monitor the antimicrobial resistance of vancomycin-resistant Enterococcus faecium (VREF).METHODS:
Two hundred and two E. faecium isolated in 10 teaching hospital were studied. To detect VRE, the brain heart infusion agar containing 6 /mL vancomycin was used as the screening agar. The MIC was determined using agar dilution test. The vancomycin resistance genes (vanA, vanB & vanD) and genes (aac(6 ') Ie-aph(2 ") Ia & ant(6 ') Ia encoding the aminoglycoside-modifying enzymes were detected by multiplex PCR using specific primers.RESULTS:
Thirty-nine VREF were detected from 202 isolates. All had vancomycin MICs > or =256 /mL and harboured vanA gene. No isolates revealed positive results for the vanB or vanD gene. However, the MIC range for teicoplanin was 2 to > or =256 /mL. All isolates with gentamicin MIC > or = 500 /mL gave positive results for the aac(6 ') Ie aph(2 ") Ia genes and with streptomycin > or =2000 /mL gave positive results for the ant(6 ') Ia gene.CONCLUSIONS:
All VREF harboured vanA gene. According to MIC tests, 7 isolates(18%) showed intermediate or susceptible to teicoplanin. Therefore we need a study concerning the clinical meaning. The VREF in Korea contain at least one of genes encoding the aminoglycoside-modifying enzymes. This means there are only limited numbers of antibiotics to choose.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Encéphale
/
Gentamicine
/
Streptomycine
/
Vancomycine
/
Dépistage de masse
/
Infection croisée
/
Enterococcus faecium
/
Enterococcus
/
Téicoplanine
/
Résistance à la vancomycine
Type d'étude:
Étude de dépistage
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Korean Journal of Clinical Microbiology
Année:
2003
Type:
Article
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