Influence of Gender on Serum Growth Hormone, Insulin-Like Growth Factor-I and Its Binding Protein-3 during Aging
Yonsei Medical Journal
;
: 407-413, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-110994
ABSTRACT
PURPOSE:
The serum concentrations of insulin-like growth factors-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and growth hormone (GH) are related to body composition, function and metabolism, and are influenced by the aging process. This study was to investigate the influence of gender on serum concentrations of IGF-I, IGFBP-3 and GH in middle and old age subjects. MATERIALS ANDMETHODS:
Sixty healthy volunteers (male 35, female 25, 36-70 years) were divided into 50 years groups, based on gender. Women > 50 years were post-menopause. IGF-I, IGFBP-3, and GH were determined by immunoradiometric assay.RESULTS:
IGF-I was shown to be negatively correlated with age (women r = -0.62, p 50 years showed a significant reduction in IGF-I values than women 50 years showed smaller IGF-I/IGFBP-3 molar ratios (0.177998 +/- 0.039404) than men of same age group (0.228326 +/- 0.050979, p < 0.01) and women < or = 50 years (0.247667 +/- 0.069411, p < 0.01). Age was shown to positively correlate with GH/IGF-I (r = 0.49, p < 0.05) and GH/IGFBP-3 ratios (r = 0.40, p < 0.05) in women.CONCLUSIONS:
The influence of aging on serum concentrations of IGF-I is more remarkable in women than in men. Menopause causes reduction of IGF-I/IGFBP-3 molar ratio. Women have the trend of progressive hypoactivity of GH to stimulate IGF-I and IGFBP-3 secretions with age.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Vieillissement
/
Facteur de croissance IGF-I
/
Dosage radioimmunométrique
/
Facteurs sexuels
/
Facteurs âges
/
Régulation de l'expression des gènes au cours du développement
/
Protéine-3 de liaison aux IGF
/
Hormone de croissance humaine
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2009
Type:
Article
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