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Clinical Implications of the Serum Apelin Level on Portal Hypertension and Prognosis of Liver Cirrhosis
Gut and Liver ; : 109-116, 2016.
Article Dans Anglais | WPRIM | ID: wpr-111610
ABSTRACT
BACKGROUND/

AIMS:

Levels of serum apelin (s-apelin), an endogenous ligand for angiotensin-like receptor 1, have been shown to be related to hepatic fibrosis and hemodynamic abnormalities in preclinical studies. We investigated the clinical implications of s-apelin as a noninvasive prognostic biomarker for chronic liver disease (CLD).

METHODS:

From January 2009 to December 2012, 215 CLD patients were enrolled and underwent clinical data collection, hepatic venous pressure gradient (HVPG) measurement, and liver biopsy. s-apelin was detected with a human total apelin enzyme-linked immunosorbent assay kit. All patients were prospectively observed during the median follow-up period of 23.0±12.9 months for decompensation and mortality.

RESULTS:

A total of 42 patients (19.5%) died during the follow-up period. s-apelin was significantly correlated with measurements of liver stiffness (R2=0.263, p<0.001) and collagen proportional area (R2=0.213, p<0.001) measured from liver biopsy tissue and HVPG (R2=0.356, p<0.001). In a multivariate analysis using a Cox regression hazard model, s-apelin was a weakly significant predictor of decompensation (hazard ratio [HR], 1.002; p<0.001) and mortality (HR, 1.003; p<0.001).

CONCLUSIONS:

s-apelin showed a significant relationship with CLD severity. However, its significance as a noninvasive biomarker for disease severity and prognosis was weak.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Biopsie / Test ELISA / Marqueurs biologiques / Modèles des risques proportionnels / Études prospectives / Études de suivi / Pression portale / Protéines et peptides de signalisation intercellulaire / Hypertension portale Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: Gut and Liver Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Biopsie / Test ELISA / Marqueurs biologiques / Modèles des risques proportionnels / Études prospectives / Études de suivi / Pression portale / Protéines et peptides de signalisation intercellulaire / Hypertension portale Type d'étude: Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: Gut and Liver Année: 2016 Type: Article