A Case of Hemophagocytic Lymphohistiocytosis with Clonal Karyotype Abnormalities
Laboratory Medicine Online
;
: 110-114, 2011.
Article
Dans Coréen
| WPRIM
| ID: wpr-111801
ABSTRACT
There have been a few reports of hemophagocytic lymphohistiocytosis (HLH) with chromosomal abnormalities. Clonal chromosomal abnormalities in HLH patients are usually found in association with hematologic malignancies and rarely with epstein-barr virus (EBV) infection. Here, we report a fatal case of HLH with clonal karyotype abnormalities. A 75-yr-old man was admitted with persistent anorexia and high fever. Laboratory data revealed pancytopenia, hypofibrinogenemia, hyperferritinemia, prolonged prothrombin time and activated partial thromboplastin time, and marked elevated level of serum transaminases. In real time-PCR using whole blood, EBV DNA was not detected but cytomegalovirus (CMV) DNA was detected. The bone marrow aspiration smear showed hyperplasia of mature histiocytes with prominent hemophagocytosis. In chromosomal analysis of bone marrow aspirates, complex chromosomal abnormalities were found. In spite of steroid pulse therapy and antibiotic treatment, he died of disseminated intravascular coagulopathy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pancytopénie
/
Temps partiel de thromboplastine
/
Temps de prothrombine
/
Moelle osseuse
/
ADN
/
Anorexie
/
Aberrations des chromosomes
/
Herpèsvirus humain de type 4
/
Tumeurs hématologiques
/
Cytomegalovirus
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Laboratory Medicine Online
Année:
2011
Type:
Article
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