Significant fibrosis after radiation therapy in a patient with Marfan syndrome
Radiation Oncology Journal
;
: 208-212, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-112697
ABSTRACT
Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor beta 1 (TGF-beta1) can be monitored as a predictor of subsequent fibrosis in this population of high risk patients. We therefore monitored the patient's TGF-beta1 level during and after treatment. Despite maintaining stable levels of plasma TGF-beta1, our patient still developed extensive fibrosis resulting in impaired range of motion. Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Maladies vasculaires
/
Fibrose
/
Plexus brachial
/
Marqueurs biologiques
/
Amplitude articulaire
/
Facteur de croissance transformant bêta
/
Collagène
/
Diagnostic
/
Facteur de croissance transformant bêta-1
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Radiation Oncology Journal
Année:
2014
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS