Helicobacter pylori Infection and Peptic Ulcer Disease in Patients with Liver Cirrhosis
The Korean Journal of Internal Medicine
; : 16-21, 2008.
Article
de En
| WPRIM
| ID: wpr-114575
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: We investigated the prevalence and relationship of peptic ulcer disease and Helicobacter pylori infection to liver cirrhosis. METHODS: We examined 288 patients with liver cirrhosis, 322 patients with non-ulcer dyspepsia, and 339 patients with peptic ulcer disease. Rapid urease test and Wright-Giemsa staining were used for diagnosis of H. pylori infection. RESULTS: The prevalence of peptic ulcer disease in patients with cirrhosis was 24.3%. The prevalence of peptic ulcer disease in patients with cirrhosis divided into Child-Pugh classes A, B, and C was 22.3%, 21.0%, and 31.3%, respectively (p>0.05). The prevalence of H. pylori infection in the patients with cirrhosis, non-ulcer dyspepsia, and peptic ulcer without chronic liver disease were 35.1%, 62.4%, and 73.7%, respectively (p0.05). The prevalence of H. pylori infection in patients with hepatitis virus-related liver cirrhosis and in the patients with alcohol-related liver cirrhosis was 42.5% and 22.0%, respectively (p<0.001). The prevalence of H. pylori infection in patients with Child-Pugh classes A, B, and C liver cirrhosis was 51.5%, 30.5%, and 20.0%, respectively (p<0.001). CONCLUSIONS: Factors other than H. pylori may be involved in the pathogenesis of peptic ulcer disease in the setting of liver cirrhosis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Ulcère gastrique
/
Indice de gravité de la maladie
/
Prévalence
/
Helicobacter pylori
/
Infections à Helicobacter
/
Cirrhose du foie
Type d'étude:
Prevalence_studies
Limites du sujet:
Adult
/
Female
/
Humans
/
Male
langue:
En
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2008
Type:
Article