Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin
The Korean Journal of Parasitology
;
: 123-126, 2005.
Article
Dans Anglais
| WPRIM
| ID: wpr-115349
ABSTRACT
Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10 beta-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasmodium falciparum
/
Résistance aux substances
/
Chloroquine
/
Artémisinines
/
Antipaludiques
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
The Korean Journal of Parasitology
Année:
2005
Type:
Article
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