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The Study of 5,10-Methylenetetrahydrofolate Reductase Variation (MTHFR C677T) in Infertile Females with Polycystic Ovarian Syndrome (PCOS) in Korea / 대한불임학회지
Korean Journal of Fertility and Sterility ; : 217-222, 2003.
Article Dans Coréen | WPRIM | ID: wpr-115412
ABSTRACT

OBJECTIVE:

To investigate the association of genetic background between MTHFR C677T genotype and infertile females with polycystic ovarian syndrome. MATERIALS AND

METHODS:

We compared 86 infertile females with polycystic ovarian syndrome (PCOS) with 100 healthy fertile females with one or more offspring. Pyrosequencing analysis for MTHFR C677T variation was performed on polymerase chain reaction (PCR) product of study group. To validate pyrosequencing data of C677T variation for randomly selected 50 samples, we compared the pyrosequencing result with the PCR-RFLP (Restriction Fragment Length Polymorphism) result of MTHFR C677T genotype.

RESULTS:

The prevalence of the C677T mutant homozygous (TT) was significantly lower (p=0.0085) in females with PCOS (8.14%) than in fertile females (21.00%). MTHFR 677 TT genotype had a decreased risk (3.7-fold) of PCOS compared with wild type (MTHFR 677 CC).

CONCLUSION:

Our data support a role for MTHFR mutant homozygous (677 TT) genotype in reducing risk in Korean infertile females with Polycystic ovarian syndrome.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Oxidoreductases / Syndrome des ovaires polykystiques / Réaction de polymérisation en chaîne / Prévalence / Génotype / Corée Type d'étude: Étude de prévalence Limites du sujet: Femelle / Humains Pays comme sujet: Asie langue: Coréen Texte intégral: Korean Journal of Fertility and Sterility Année: 2003 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Oxidoreductases / Syndrome des ovaires polykystiques / Réaction de polymérisation en chaîne / Prévalence / Génotype / Corée Type d'étude: Étude de prévalence Limites du sujet: Femelle / Humains Pays comme sujet: Asie langue: Coréen Texte intégral: Korean Journal of Fertility and Sterility Année: 2003 Type: Article