Establishment of Trimester-Specific Reference Intervals for Thyroid Hormones in Korean Pregnant Women
Annals of Laboratory Medicine
;
: 198-204, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-115858
ABSTRACT
BACKGROUND:
Establishment of trimester- and assay-specific reference intervals for every population is recommended. The aim of this study was to establish a trimester- and assay-specific reference interval for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in Korean pregnant women.METHODS:
From April 2012 to December 2012, 531 pregnant women receiving prenatal care and 238 age-matched, non-pregnant women were enrolled in this study. After excluding patients with pregnancy-associated complications or thyroid-specific autoantibody, 465 pregnant and 206 non-pregnant women were included. Non-parametric analysis (2.5-97.5th percentile) was performed to determine the reference interval. Levels of TSH and FT4 were determined by electrochemiluminescence immunoassay (Elecsys thyroid tests, Roche Diagnostics, Germany).RESULTS:
The TSH reference intervals were 0.01-4.10, 0.01-4.26, and 0.15-4.57 mIU/L for the first, second, and third trimester, respectively. From the first trimester to the third trimester, the median TSH levels showed a significantly increasing trend (P<0.0001). The FT4 reference intervals were 0.83-1.65, 0.71-1.22, and 0.65-1.13 ng/dL for the first, second, and third trimester, respectively, showing a significantly decreasing trend (P<0.0001).CONCLUSIONS:
Establishing trimester-specific reference intervals in pregnant women is essential for accurate assessment of thyroid function. Our population-specific and method-specific reference intervals will be useful for screening Korean pregnant women for thyroid disease.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Trimestres de grossesse
/
Prise en charge prénatale
/
Valeurs de référence
/
Hormones thyroïdiennes
/
Thyroxine
/
Dosage immunologique
/
Études cas-témoins
/
Asiatiques
/
République de Corée
/
Mesures de luminescence
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Grossesse
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Annals of Laboratory Medicine
Année:
2015
Type:
Article
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