A Case of Cold Agglutinin Disease Accompanied by Bacterial Pneumonia That Was Treated with Rituximab / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 253-257, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-116845
ABSTRACT
Cold agglutinin disease (CAD) is a small group of disorders that is characterized by cold-reactive autoantibodies that bind to erythrocyte carbohydrate antigens, and this causes hemagglutination and complement-mediated hemolysis. Autoimmune hemolytic anemia (AIHA) is an immune disorder that is mediated via auto-antibodies produced by lymphoid B cells against red blood cells. The disorder may be a primary (idiopathic) or secondary disease with an underlying autoimmune disease, a lymphoproliferative disorder or infection. The mainstay of initial treatment is immunosuppression with glucocorticosteroids. For those who do not have satisfactory response to initial glucocorticosteroids or they have a relapse after initially successful treatment, splenectomy or other immunosuppressive agents such as azathioprine, cyclosporine and intravenous immunoglobulin (IVIG) could be the next available options. More recently, rituximab, which is a human-murine chimeric monoclonal antibody specific for the CD20 antigen found on the surface of B lymphocytes, is also available. We report here on the successful use of rituximab for the treatment of a Korean elderly patient with CAD and the patient presented with recurrent AIHA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
Autoanticorps
/
Maladies auto-immunes
/
Splénectomie
/
Azathioprine
/
Immunoglobulines
/
Lymphocytes B
/
Immunosuppression thérapeutique
/
Ciclosporine
/
Basse température
Limites du sujet:
Adulte très âgé
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Blood Transfusion
Année:
2009
Type:
Article
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