Development of Monoclonal Antibodies Recognizing Human Peripheral Blood T Lymphocytes Cytoplasmic Proteins Induced upon Activation / 대한면역학회지
Korean Journal of Immunology
; : 145-156, 1997.
Article
de Ko
| WPRIM
| ID: wpr-117925
Bibliothèque responsable:
WPRO
ABSTRACT
Antigen-specific T cell activation requires interaction of the T cell with specialized antigen-presenting cells. Signaling through the TCR is necessary but not sufficient to induce antigen-specific T cell activation and cytokine secretion. This first signal, termed signal 1, is both antigen-specific and MHC-restricted. Signal 2, which is neither antigen-specific nor MHC-restricted, is necessary to induce cytokine secretion, cellular proliferation, and effector function. Recently immunological studies in T cell activation area are mainly focused on biological and molecular biological characterization of TCR/CD3 complex and accessary molecules providing costimulatory signal (signal 2). If signal 2 is not delivered, T cell enter a state of long term un-responsiveness to specific antigen-termed anergy. Monoclonal antibody technique has been especially involved in recognizing novel inducible cell surface antigens on T cell activation. This study was aimed to develop monoclonal antibodies recognizing novel cytoplasmic proteins present in activated T cells. We make 6 monoclones involved in changing pattern of T cell activated cytoplasmic proteins. Using these 6 monoclonal antibodies analyze to find novel molecules involved in T cell activation associated response, apoptosis, and/or heat shock response of the T cells in early T cell activation.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Lymphocytes T
/
Apoptose
/
Réaction de choc thermique
/
Cytoplasme
/
Prolifération cellulaire
/
Protéines du choc thermique
/
Anticorps monoclonaux
/
Cellules présentatrices d'antigène
/
Antigènes de surface
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Immunology
Année:
1997
Type:
Article