Detection of Y Chromosome-specific Sequences in Patients with Turner Syndrome / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 2244-2249, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-118704
ABSTRACT
Existence of Y derived chromosome in Turner patients is significant due to the risk of gonadoblastoma development, but cytogenetic analysis may fail to detect low levels of Y chromosomal materials. Recent studies using PCR based methods showed higher sensitivity to detect Y-specific sequences, in patients who were Y chromosome-negative cytogenetically. In this study PCR was performed on 44 Turner patients with no Y chromosome by cytogenetic analysis to detect the SRY, AMELY, ZFY, and DYZ1 sequences. Of seven patients whose karyotypes were 45,X/46,X,+mar, three patients were positive for SRY, ZFY, and AMELY. DYZ1 sequences was negative in them. And any of SRY, ZFY, AMELY, and DYZ1 sequences was detected in the remaining 37 patients. This result shows that PCR analysis for Y-specific sequences in Turner patients, especially in patients who have marker chromosome is a significant effort.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Syndrome de Turner
/
Chromosome Y
/
Réaction de polymérisation en chaîne
/
Gonadoblastome
/
Analyse cytogénétique
/
Gène sry
/
Caryotype
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2002
Type:
Article
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