Association between Elevated Pleural Interleukin-33 Levels and Tuberculous Pleurisy
Annals of Laboratory Medicine
; : 45-51, 2013.
Article
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| ID: wpr-119341
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ABSTRACT
BACKGROUND: Interferon-gamma (IFN-gamma) plays a crucial role in Mycobacterium tuberculosis induced pleural responses. Interleukin (IL)-33 up-regulates the production of IFN-gamma. We aimed to identify whether an association between pleural IL-33 levels and tuberculous pleurisy exists and determine its diagnostic value. METHODS: Pleural IL-33, ST2 (a receptor of IL-33), adenosine deaminase (ADA), and IFN-gamma, as well as serum IL-33 and ST2 were measured in 220 patients with pleural effusions (PEs). Patients with malignant (MPEs), parapneumonic (PPEs), tuberculous (TPEs), and cardiogenic (CPEs) pleural effusions were included. RESULTS: Pleural and serum IL-33 levels were highest or tended to be higher in patients with TPEs than in those with other types of PEs. The median pleural fluid-to-serum IL-33 ratio was higher in TPE cases (> or = 0.91) than in other PE cases (< or = 0.56). Pleural IL-33 levels correlated with those of pleural ADA and IFN-gamma. However, the diagnostic accuracies of pleural IL-33 (0.74) and pleural fluid-to-serum IL-33 ratio (0.75) were lower than that of ADA (0.95) or IFN-gamma (0.97). Pleural ST2 levels in patients with MPEs were higher than in patients with TPEs. Serum ST2 levels did not differ among the groups. CONCLUSIONS: We identified an association between elevated pleural IL-33 levels and tuberculous pleurisy. However, we recommend conventional pleural markers (ADA or IFN-gamma) as diagnostic markers of TPE.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Épanchement pleural
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Tuberculose pleurale
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Études cas-témoins
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Adenosine deaminase
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Études transversales
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Courbe ROC
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Épanchement pleural malin
/
Interleukines
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Interféron gamma
/
Récepteurs de surface cellulaire
Type d'étude:
Observational_studies
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Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
langue:
En
Texte intégral:
Annals of Laboratory Medicine
Année:
2013
Type:
Article