Vitamin D Receptor Poly(A) Microsatellite Polymorphism and 25-Hydroxyvitamin D Serum Levels: Association with Susceptibility to Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
;
: 119-125, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-119571
ABSTRACT
PURPOSE:
According to previous studies, vitamin D exhibits protective effects against breast cancer via the vitamin D receptor (VDR). There is growing evidence that breast cancer incidence is associated with various polymorphisms of the VDR gene. This study investigates the association of VDR poly(A) microsatellite variants with 25-hydroxyvitamin D (25(OH)D) serum levels and breast cancer risk.METHODS:
Polymorphism analysis was performed on a total of 261 blood samples, which were collected from 134 women with breast cancer and 127 controls. Single strand conformation polymorphism was assessed by polymerase chain reaction in combination with sequencing to detect poly(A) lengths for each sample. The vitamin D levels of samples were determined by electrochemiluminescence.RESULTS:
The poly(A) variant L allele frequency was significantly higher in cancer patients than in controls (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.16-2.57; p=0.006). Thus, carriers of the L allele (LS and LL genotypes) have a higher risk for breast cancer (OR, 1.86; 95% CI, 1.13-3.05; p=0.013). A larger increase in the risk for breast cancer was found in individuals with the L carrier genotype and lowered 25(OH)D levels.CONCLUSION:
The results primarily suggest that VDR gene polymorphism in the poly(A) microsatellite is associated with 25(OH)D levels and that it can affect the breast cancer risk in the female population from northern Iran.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Vitamine D
/
Tumeurs du sein
/
25-Hydroxyvitamine D2
/
Réaction de polymérisation en chaîne
/
Incidence
/
Récepteur calcitriol
/
Répétitions microsatellites
/
Allèles
/
Fréquence d'allèle
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Femelle
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Journal of Breast Cancer
Année:
2015
Type:
Article
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