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Interleukin-1beta Promoter Polymorphisms in Febrile Seizures and GEFS+ / 대한소아신경학회지
Journal of the Korean Child Neurology Society ; (4): 113-120, 2006.
Article Dans Coréen | WPRIM | ID: wpr-119887
ABSTRACT

PURPOSE:

Studies gave conflicting results as to the association between febrile seizures(FSs) and IL1B promoter polymorphisms. In the present study, to determine whether or not the function-related two single nucleotide base C/T biallelic polymorphisms in the promoter region at positions -31 and -511 of the IL1B gene are associated with susceptibility to FSs, the frequencies of the polymorphisms were investigated in children with FSs and GEFS+, and normal control subjects.

METHODS:

72 FSs, 23 GEFS+ and 174 healthy control subjects were selected throughout a collaborative study of Catholic Child Neurology Research Group. IL1B promoter -31 C/T and -511 C/T genotyping was performed by means of PCR-restriction fragment length polymorphism.

RESULTS:

The distribution of IL1B -31 genotypes and the frequencies of allele in children with FSs and GEFS+, and healthy control subjects were not significantly different. The distributions of IL1B -31 genotypes(CC, CT, TT) are 22.2%, 50%, and 27.8% in children with FSs, 21.7%, 43.5% and 34.8% in children with GEFS+, and 27.6%, 49.3% and 24.1% in healthy control subjects. The distribution of IL1B -511 genotypes and the frequencies of allele in children with FSs and GEFS+, and healthy control subjects were not significantly different. The distributions of IL1B -511 genotypes(CC, CT, TT) are 23.6%, 47.2%, and 29.2% in children with FSs, 26.1%, 39.1% and 34.8% in children with GEFS+, and 27.6%, 49.3% and 24.1% in healthy control subjects.

CONCLUSION:

Theses data suggest that genomic variations of IL1B promoter might not be one of the susceptibility factors for FSs in the Korean population.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Régions promotrices (génétique) / Crises convulsives fébriles / Allèles / Interleukine-1 bêta / Génotype / Neurologie Limites du sujet: Enfant / Humains langue: Coréen Texte intégral: Journal of the Korean Child Neurology Society Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Régions promotrices (génétique) / Crises convulsives fébriles / Allèles / Interleukine-1 bêta / Génotype / Neurologie Limites du sujet: Enfant / Humains langue: Coréen Texte intégral: Journal of the Korean Child Neurology Society Année: 2006 Type: Article