Interleukin-1beta Promoter Polymorphisms in Febrile Seizures and GEFS+ / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 113-120, 2006.
Article
Dans Coréen
| WPRIM
| ID: wpr-119887
ABSTRACT
PURPOSE:
Studies gave conflicting results as to the association between febrile seizures(FSs) and IL1B promoter polymorphisms. In the present study, to determine whether or not the function-related two single nucleotide base C/T biallelic polymorphisms in the promoter region at positions -31 and -511 of the IL1B gene are associated with susceptibility to FSs, the frequencies of the polymorphisms were investigated in children with FSs and GEFS+, and normal control subjects.METHODS:
72 FSs, 23 GEFS+ and 174 healthy control subjects were selected throughout a collaborative study of Catholic Child Neurology Research Group. IL1B promoter -31 C/T and -511 C/T genotyping was performed by means of PCR-restriction fragment length polymorphism.RESULTS:
The distribution of IL1B -31 genotypes and the frequencies of allele in children with FSs and GEFS+, and healthy control subjects were not significantly different. The distributions of IL1B -31 genotypes(CC, CT, TT) are 22.2%, 50%, and 27.8% in children with FSs, 21.7%, 43.5% and 34.8% in children with GEFS+, and 27.6%, 49.3% and 24.1% in healthy control subjects. The distribution of IL1B -511 genotypes and the frequencies of allele in children with FSs and GEFS+, and healthy control subjects were not significantly different. The distributions of IL1B -511 genotypes(CC, CT, TT) are 23.6%, 47.2%, and 29.2% in children with FSs, 26.1%, 39.1% and 34.8% in children with GEFS+, and 27.6%, 49.3% and 24.1% in healthy control subjects.CONCLUSION:
Theses data suggest that genomic variations of IL1B promoter might not be one of the susceptibility factors for FSs in the Korean population.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Régions promotrices (génétique)
/
Crises convulsives fébriles
/
Allèles
/
Interleukine-1 bêta
/
Génotype
/
Neurologie
Limites du sujet:
Enfant
/
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Child Neurology Society
Année:
2006
Type:
Article
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