The Change of Prostate Specific Antigen after Treatment in Chronic Prostatitis Associated with Elevated Serum Prostate Specific Antigen / 대한비뇨기과학회지
Korean Journal of Urology
;
: 819-822, 2003.
Article
Dans Coréen
| WPRIM
| ID: wpr-120320
ABSTRACT
PURPOSE:
Men with documented chronic prostatitis, with elevated serum prostate specific antigen (PSA), were investigated to assess whether treatment lowers serum PSA and thus avoids unnecessary biopsies. MATERIALS ANDMETHODS:
The medical records of 46 men who presented with serum PSA higher than 4ng/ml, and subsequently diagnosed with chronic prostatitis, were retrospectively reviewed. After the administration of antibiotics and anti-inflammatory drugs for 4 to 8 weeks, the follow-up PSA levels were determined, and those with levels higher than 4ng/ml underwent a prostate biopsy.RESULTS:
The mean PSA level decreased 61% from 11.66ng/ml before, to 3.79ng/ml after, treatment (p<0.001). In 30 patients the serum PSA level decreased to below 4ng/ml (mean 1.69), with these patients no longer having an indication for a prostate biopsy. In the remaining 16 patients the serum PSA level remained elevated above 4ng/ml, so they underwent a prostate biopsy. Pathological study revealed benign prostatic hyperplasia in 11 cases and prostate cancer in 5. The PSA level in patients associated with benign prostatic hyperplasia decreased 61.9% with treatment, from 19.96 to 7.88ng/ml (p=0.006) and the PSA in those associated with prostate cancer decreased 30.6% with treatment, from 12.85 to 7.32ng/ml (p<0.05).CONCLUSIONS:
This study demonstrates that chronic prostatitis can cause elevation of serum PSA levels, and when identified, antibiotics and anti-inflammatory treatment can lower these levels and an unnecessary prostate biopsy can be avoided.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Prostate
/
Hyperplasie de la prostate
/
Tumeurs de la prostate
/
Prostatite
/
Biopsie
/
Dossiers médicaux
/
Études rétrospectives
/
Études de suivi
/
Antigène spécifique de la prostate
/
Antibactériens
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Korean Journal of Urology
Année:
2003
Type:
Article
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