Distinct Mutation of p53 Gene in Bladder Cancer of Smoking and Nonsmoking Patients / 대한비뇨기과학회지
Korean Journal of Urology
;
: 247-250, 1998.
Article
Dans Coréen
| WPRIM
| ID: wpr-120656
ABSTRACT
PURPOSE:
It is well known that smoking is one of the most important etiologic factor in bladder cancer and mutations of p53 tumor suppressor gene are the important step in carcinogenesis of urinary bladder. In this study, we investigated the difference in pattern and rate of p53 gene mutation between smoker and non-smoker MATERIALS ANDMETHODS:
Of 26 bladder transitional cell carcinoma, 16 cases were smoker and 10 cases were non-smoker. We evaluated mutation of the p53 gene concentrated on axon 5 through 8, using polymerase chain reaction- single strand conformation polymorphism(PCR-SSCP) with radioisotope.RESULTS:
3 cases(18.7%) of 16 smoker were found to have p53 gene mutation, but none of 10 non-smoker was found. 2 of 3 cases of p53 gene mutation were found in exon 5 and 1 in exon 7. The pattern of p53 gene mutation was different in 3 cases.CONCLUSIONS:
Although the more cases will be needed in this study, we think that a mutation of p53 in bladder cancer may be associated with cigarette smoking.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Fumée
/
Axones
/
Vessie urinaire
/
Tumeurs de la vessie urinaire
/
Carcinome transitionnel
/
Fumer
/
Exons
/
Gènes p53
/
Gènes suppresseurs de tumeur
/
Carcinogenèse
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Urology
Année:
1998
Type:
Article
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