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Correlation between TSH Receptor Antibody Assays and Clinical Manifestations of Graves' Orbitopathy
Yonsei Medical Journal ; : 1033-1039, 2013.
Article Dans Anglais | WPRIM | ID: wpr-121783
ABSTRACT

PURPOSE:

To investigate an association between the levels of serum thyroid-stimulating hormone (TSH)-receptor autoantibodies (TRAbs) and Graves' orbitopathy (GO) activity/severity scores, and compare the performance of three different TRAb assays in assessing the clinical manifestations of GO. MATERIALS AND

METHODS:

Cross-sectional study. Medical records of 155 patients diagnosed with GO between January 2008 and December 2010 were reviewed. GO activity was assessed by clinical activity score (CAS) and severity graded with the modified NOSPECS score by a single observer. Serum TRAb was measured by three different

methods:

1st generation thyrotropin-binding inhibitor immunoglobulin (TBII) assay (TRAb1st); 3rd generation TBII assay (TRAb3rd); and biological quantitative assay of thyroid-stimulating immunoglobulin (TSI) using Mc4-CHO cells (Mc4-CHO TSI assay). Results were correlated with scores of activity/severity of thyroid eye disease.

RESULTS:

All three assays (TRAb1st, TRAb3rd, and Mc4-CHO TSI) yielded results that were significantly positively correlated with CAS (beta=0.21, 0.21, and 0.46, respectively; p<0.05) and proptosis (beta=0.38, 0.34, and 0.33, respectively; p<0.05). Mc4-CHO TSI bioassay results were significantly positively correlated with all GO severity indices (soft tissue involvement, proptosis, extraocular muscle involvement, and total eye score; beta=0.31, 0.33, 0.25, and 0.39, respectively; p<0.05).

CONCLUSION:

Mc4-CHO TSI bioassay was superior over the two TBIIs in assessing active inflammation and muscle restriction due to GO, whereas TBII assay would be sufficient for evaluation of patients with proptosis.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Autoanticorps / Récepteur TSH / Dosage immunologique / Études transversales / Cricetulus / Cellules CHO / Ophtalmopathie basedowienne Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Animaux / Femelle / Humains / Mâle langue: Anglais Texte intégral: Yonsei Medical Journal Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Autoanticorps / Récepteur TSH / Dosage immunologique / Études transversales / Cricetulus / Cellules CHO / Ophtalmopathie basedowienne Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Animaux / Femelle / Humains / Mâle langue: Anglais Texte intégral: Yonsei Medical Journal Année: 2013 Type: Article