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Antimicrobial Susceptibility Patterns of Legionella isolates in the Environment and in Patients / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine ; : 28-33, 2010.
Article Dans Coréen | WPRIM | ID: wpr-121790
ABSTRACT

BACKGROUND:

Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics.

METHODS:

We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concentrations (MICs) of 6 antibiotics, namely, azithromycin, ciprofloxacin, clarithromycin, clindamycin, gatifloxacin, and gemifloxacin were determined by the broth microdilution method using buffered starch yeast extract broth.

RESULTS:

The MIC ranges of the 6 antibiotics used against the Legionella isolates were as follows 0.004-0.062 microgram/mL (azithromycin), 0.002-0.5 microgram/mL (ciprofloxacin), 0.004-0.5 microgram/mL (clarithromycin), 0.12-4 microgram/mL (clindamycin), 0.002-0.12 microgram/mL (gatifloxacin), and 0.008-1 microgram/mL (gemifloxacin).

CONCLUSIONS:

Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Légionellose / Legionella / Clindamycine / Ciprofloxacine / Tests de sensibilité microbienne / Clarithromycine / Azithromycine / Fluoroquinolones / Résistance bactérienne aux médicaments / Antibactériens Limites du sujet: Humains langue: Coréen Texte intégral: The Korean Journal of Laboratory Medicine Année: 2010 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Légionellose / Legionella / Clindamycine / Ciprofloxacine / Tests de sensibilité microbienne / Clarithromycine / Azithromycine / Fluoroquinolones / Résistance bactérienne aux médicaments / Antibactériens Limites du sujet: Humains langue: Coréen Texte intégral: The Korean Journal of Laboratory Medicine Année: 2010 Type: Article