A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment / 대한내과학회지
Korean Journal of Medicine
; : 261-265, 2010.
Article
de Ko
| WPRIM
| ID: wpr-121796
Bibliothèque responsable:
WPRO
ABSTRACT
Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced by low-dose ADV. A 61-year-old man suffering from chronic hepatitis B manifested with generalized myalgia and bone pain, especially in both ankles and knees. He had been administered ADV for 56 months, since lamivudine-resistant HBV was detected. He developed severe hypophosphatemia and elevated serum alkaline phosphatase levels with a high bone fraction. Bone densitometry and a whole-body bone scan revealed osteoporosis and multiple hot uptake lesions. Blood chemistry and clinical symptoms improved after discontinuing the ADV.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Ostéomalacie
/
Ostéoporose
/
Stress psychologique
/
Adénine
/
Virus de l'hépatite B
/
Hypophosphatémie
/
Hépatite B chronique
/
Créatinine
/
Densitométrie
/
Phosphatase alcaline
Limites du sujet:
Animals
/
Humans
langue:
Ko
Texte intégral:
Korean Journal of Medicine
Année:
2010
Type:
Article