Suppression of Aurora-A oncogenic potential by c-Myc downregulation
Experimental & Molecular Medicine
;
: 759-767, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-122640
ABSTRACT
The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Lignée de cellules transformées
/
Régulation négative
/
Régulation de l'expression des gènes tumoraux
/
Activation de la transcription
/
Transformation cellulaire néoplasique
/
Protéines proto-oncogènes c-myc
/
Cisplatine
/
Protein-Serine-Threonine Kinases
/
Transgènes
/
Petit ARN interférent
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2010
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS