Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Action
Annals of Dermatology
;
: 1-6, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-122686
ABSTRACT
Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a major ingredient in topical pharmacological agents. However, frequent adverse reactions are amongst its major limitation. To solve this problem, several alternatives such as arbutin, kojic acid, aloesin, and 4-n-butyl resorcinol have been developed. Herein, we classify hypopigmenting agents according to their mechanism of action; a) regulation of enzyme, which is subdivided into three categories, i) regulation of transcription and maturation of tyrosinase, ii) inhibition of tyrosinase activity, and iii) post-transcriptional control of tyrosinase; b) inhibition of melanosome transfer, and c) additional mechanisms such as regulation of the melanocyte environment and antioxidant agents.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Arbutoside
/
Pyrones
/
Résorcinol
/
Tyrosine
/
4H-1-Benzopyran-4-ones
/
Monophenol monooxygenase
/
Hypopigmentation
/
Mélanosomes
/
Glucosides
/
Hydroquinones
langue:
Anglais
Texte intégral:
Annals of Dermatology
Année:
2012
Type:
Article
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