Adjuvant sequential chemo and radiotherapy improves the oncological outcome in high risk endometrial cancer / 부인종양
Journal of Gynecologic Oncology
; : 284-292, 2015.
Article
de En
| WPRIM
| ID: wpr-123438
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: Evaluation of the impact of sequential chemoradiotherapy in high risk endometrial cancer (EC). METHODS: Two hundred fifty-four women with stage IB grade 3, II and III EC (2009 FIGO staging), were included in this retrospective study. RESULTS: Stage I, II, and III was 24%, 28.7%, and 47.3%, respectively. Grade 3 tumor was 53.2% and 71.3% had deep myometrial invasion. One hundred sixty-five women (65%) underwent pelvic (+/- aortic) lymphadenectomy and 58 (22.8%) had nodal metastases. Ninety-eight women (38.6%) underwent radiotherapy, 59 (23.2%) chemotherapy, 42 (16.5%) sequential chemoradiotherapy, and 55 (21.7%) were only observed. After a median follow-up of 101 months, 78 women (30.7%) relapsed and 91 women (35.8%) died. Sequential chemoradiotherapy improved survival rates in women who did not undergo nodal evaluation (disease-free survival [DFS], p=0.040; overall survival [OS], p=0.024) or pelvic (+/- aortic) lymphadenectomy (DFS, p=0.008; OS, p=0.021). Sequential chemoradiotherapy improved both DFS (p=0.015) and OS (p=0.014) in stage III, while only a trend was found for DFS (p=0.210) and OS (p=0.102) in stage I-II EC. In the multivariate analysis, only age (< or =65 years) and sequential chemoradiotherapy were statistically related to the prognosis. CONCLUSION: Sequential chemoradiotherapy improves survival rates in high risk EC compared with chemotherapy or radiotherapy alone, in particular in stage III.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Études rétrospectives
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Facteurs de risque
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Résultat thérapeutique
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Tumeurs de l'endomètre
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Traitement médicamenteux adjuvant
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Laparoscopie
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Radiothérapie adjuvante
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Chimioradiothérapie
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Lymphadénectomie
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Métastase lymphatique
Type d'étude:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Adult
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Aged
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Aged80
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Female
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Humans
langue:
En
Texte intégral:
Journal of Gynecologic Oncology
Année:
2015
Type:
Article