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Recent Trends of Antigenic Variation in Bordetella pertussis Isolates in Korea
Journal of Korean Medical Science ; : 328-333, 2014.
Article Dans Anglais | WPRIM | ID: wpr-124861
ABSTRACT
Pertussis is a representative vaccine-preventable disease. However, there have been recent outbreaks in countries where even higher vaccination against the disease. One reason is the emergence of antigenic variants, which are different to vaccine type. In Korea, reported cases have rapidly increased since 2009. Therefore, we analyzed genotype of strains isolated in 2011-2012 by multilocus sequence typing method. As expected, the genotype profiles of tested genes dramatically changed. The major sequence type changed from ST1 to ST2, and new sequence type (ST8) appeared. In the minimum spanning tree, recent isolates belonging to the ACC-I-ST3 subgroup were detected that were composed of ST2, ST3, and ST6. In particular, the ST2 frequency increased to 81%. The novel ST8 was linked to the increased frequency of ST2. In addition, toxic strains carrying the ptxP3 promoter type were confirmed. This ptxP3 type emerged from 2009 and its frequency had increased to 100% in 2012. Based on these results, it can be inferred that the genotypic changes in the currently circulating strains are strongly associated with the recent increasing of pertussis in Korea. Therefore, the surveillance system should be strengthened, and genetic characterization of the isolates should be expanded to the whole genome sequence level.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Protéines bactériennes / Bordetella pertussis / Variation des antigènes / Coqueluche / Régions promotrices (génétique) / Analyse de séquence d'ADN / Toxine pertussique / République de Corée / Gènes bactériens / Génotype Limites du sujet: Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Protéines bactériennes / Bordetella pertussis / Variation des antigènes / Coqueluche / Régions promotrices (génétique) / Analyse de séquence d'ADN / Toxine pertussique / République de Corée / Gènes bactériens / Génotype Limites du sujet: Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2014 Type: Article