Association between the Genetic Polymorphisms of the Biogenic Amine Transporters and the Antidepressant Responsiveness in Korean Depressed Patients / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 274-283, 2003.
Article
de Ko
| WPRIM
| ID: wpr-124945
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: Serotonin transporter (5-HTT) is a key synaptic regulator of serotonergic neurotransmission and a major site of action of most antidepressants. The functional polymorphism of 5-HTT gene is reported to be associated with antidepressant responsiveness. Norepinephrine transporter (NET) and dopamine transporter (DAT) are also the targets for antidepressant drugs, and these biogenic amine transporters share a similar structure and mode of action as 5-HTT. We investigated the association between genetic polymorphisms of biogenic amine transporters and antidepressant response. METHODS: We genotyped 203 patients with major depressive disorder and 147 normal controls, using polymerase chain reaction (PCR) of genomic DNA with primers flanking the second intron and promoter regions of 5-HTT gene, and the 3' untranslated region of DAT. NET-1 (Thr99Ile) and NET-8 (1287 G/A) polymorphism were characterized by amplification and restriction fragment length polymorphisms (RFLP) analysis. RESULTS: VNTR polymorphism in the 3' untranslated region of DAT (p=0.020) was associated with a diagnosis of depression, but was influenced by age effect. We found that NET-8 polymorphism (p=0.015) in NET gene had significant associations with antidepressant response, as did the allelic variations of the promoter (p<0.0001) and intron2 (p=0.023) region in 5-HTT gene. The choice of drug had no effect on drug responsiveness. CONCLUSIONS: These results suggest that allelic variations of 5-HTT and NET genes affect the antidepressant responsiveness.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polymorphisme génétique
/
Amines biogènes
/
Polymorphisme de restriction
/
ADN
/
Introns
/
Réaction de polymérisation en chaîne
/
Régions promotrices (génétique)
/
Transmission synaptique
/
Régions 3' non traduites
/
Dépression
Type d'étude:
Diagnostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Psychopharmacology
Année:
2003
Type:
Article