Clinical Study of the Acute Hepatitis due to Salmonella typhi / 대한간학회지
The Korean Journal of Hepatology
;
: 350-359, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-125021
ABSTRACT
BACKGROUND/AIM:
It is not easy to differentiate Salmonella from acute viral hepatitis (AVH), especially in the case of jaundice. Therefore we analyzed the differences between Salmonella hepatitis and AVH-B.METHOD:
Our study was performed retrospectively on 11 patients with acute hepatitis who had positive blood culture for Salmonella typhi and 11 patients with AVH-B as controls.RESULT:
The greater proportion of patients with Salmonella experienced fever, headache, diarrhea, relative bradycardia and hepatomegaly in contrast to the patients with AVH-B (p<0.05). But jaundice was detected more frequently in patients with AVH-B. The laboratory findings that were noted more in Salmonella patients than AVH-B patients were left shift of leukocyte, anemia, thrombocytopenia, hypoproteinemia, hypoalbuminemia, lower peak levels of aminotransferase and total bilirubin, a trend toward a higher peak level of serum LDH and lower ratio of ALT/LDH expressed as a multiple of the upper limit of normal level on admission (p<0.05). Acute cholecystitis was complicated in 2 patients with Salmonella. One was resolved by cholecystostomy and the other had surgical intervention. The other 9 patients recovered with appropriate administration of antibiotics.CONCLUSION:
The clues that raise the possibility of Salmonella over AVH-B include high fever, headache, diarrhea, relative bradycardia, hepatmegaly, left shift of leukocyte, anemia, thrombocytopenia, hypoproteinemia, hypoalbuminemia, a markedly elevated serum level of LDH and lower ALT/LDH ratio (less than 4) on admission. Of these, ALT/LDH ratio is the best discriminator between Salmonella and AVH-B. Early diagnosis and appropriate administration of antibiotics are necessary for the successful treatment of Salmonella.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Salmonella
/
Salmonella typhi
/
Thrombopénie
/
Bilirubine
/
Bradycardie
/
Cholécystostomie
/
Études rétrospectives
/
Hypoalbuminémie
/
Cholécystite aigüe
/
Diagnostic précoce
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de dépistage
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
The Korean Journal of Hepatology
Année:
2000
Type:
Article
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