The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants / 소아과
Korean Journal of Pediatrics
;
: 150-156, 2004.
Article
Dans Coréen
| WPRIM
| ID: wpr-125119
ABSTRACT
PURPOSE:
Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants.METHODS:
Clinical data were collected retrospectively from 478 preterm infants(gestational period< or =34 weeks) who were admitted to the neonatal intensive care unit(NICU) in Seoul National University Children's Hospital from January 1993 to December 2000.RESULTS:
Histologic chorioamnionitis(CA) was observed in 210 of 478 infants(44%). Lower gestational period was detected in CA(+) group(31+1 +/- 2+2 weeks vs. 30+1+/-2+3 weeks). CA(+) group had decreased incidence of RDS(38.4% vs. 28.1%)[odds ratio, OR 0.35(P=0.0004, 95% confidence intervals, CI 0.19-0.63)], and increased incidence of CLD(7.5% vs. 13.3%)[OR 1.95(P=0.047, 95% CI 1.01-3.79)] combined much more "atypical CLD"(10.5% vs. 55.6%). CA(+) group had decreased incidence of patent ductus arteriosus(33.3% vs. 25.4%)[OR 0.37(P=0.003, 95% CI 0.19-0.71)]. There was no difference between the two groups in birth weight.CONCLUSION:
It is suggested that intrauterine infections and fetal inflammatory responses might play a role in the outcome of preterm infants, and histologic chorioamnionitis is an isolated risk factor in the development of RDS and CLD of the preterm infants.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Poids de naissance
/
Prématuré
/
Soins intensifs néonatals
/
Incidence
/
Études rétrospectives
/
Facteurs de risque
/
Chorioamnionite
/
Naissance prématurée
/
Séoul
/
Poumon
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Korean Journal of Pediatrics
Année:
2004
Type:
Article
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