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Patients with Concordant Triple-Negative Phenotype between Primary Breast Cancers and Corresponding Metastases Have Poor Prognosis / 한국유방암학회지
Journal of Breast Cancer ; : 268-274, 2016.
Article de En | WPRIM | ID: wpr-126243
Bibliothèque responsable: WPRO
ABSTRACT
PURPOSE: We investigated the prognostic impact of discordance between the receptor status of primary breast cancers and corresponding metastases. METHODS: A total 144 patients with breast cancer and distant metastasis were investigated. The estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status of primary tumor and corresponding metastases were assessed. Tumor phenotype according to receptor status was classified as triple-negative phenotype (TNP) or non-TNP. Concordance and discordance was determined by whether there was a change in receptor status or phenotype between primary and metastatic lesions. RESULTS: The rates of discordance between primary breast cancer and metastatic lesions were 18.1%, 25.0%, and 10.3% for ER, PR, and HER2, respectively. The rates of concordant non-TNP, concordant TNP and discordant TNP were 65.9%, 20.9%, and 13.2%, respectively. Patients with concordant ER/PR-negative status had worse postrecurrence survival (PRS) than patients with concordant ER/PR-positive and discordant ER/PR status (p=0.001 and p=0.021, respectively). Patients who converted from HER2-positive to negative after distant metastasis had worst PRS (p=0.040). Multivariate analysis showed that concordant TNP was statistically significant factor for worse PRS (p<0.001). CONCLUSION: Discordance in receptor status and tumor phenotype between primary breast cancer and corresponding metastatic lesions was observed. Patients with concordant TNP had worse long-term outcomes than patients with concordant non-TNP and discordant TNP between primary and metastatic breast cancer. Identifying the receptor status of metastatic lesions may lead to improvements in patient management and survival.
Sujet(s)
Mots clés
Texte intégral: 1 Indice: WPRIM Sujet Principal: Phénotype / Pronostic / Région mammaire / Tumeurs du sein / Récepteurs à la progestérone / Analyse multifactorielle / Oestrogènes / Récepteurs ErbB / Métastase tumorale Type d'étude: Prognostic_studies Limites du sujet: Humans langue: En Texte intégral: Journal of Breast Cancer Année: 2016 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Phénotype / Pronostic / Région mammaire / Tumeurs du sein / Récepteurs à la progestérone / Analyse multifactorielle / Oestrogènes / Récepteurs ErbB / Métastase tumorale Type d'étude: Prognostic_studies Limites du sujet: Humans langue: En Texte intégral: Journal of Breast Cancer Année: 2016 Type: Article