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A Case of Lambert-Eaton Myasthenic Syndrome with Small-Cell Lung Cancer and Transient Increase in Anti-Acetylcholine-Receptor-Binding Antibody Titer
Article de En | WPRIM | ID: wpr-12699
Bibliothèque responsable: WPRO
ABSTRACT
BACKGROUND: Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased. CASE REPORT: A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L. CONCLUSIONS: We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.
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Texte intégral: 1 Indice: WPRIM Sujet Principal: Canaux calciques / Syndrome myasthénique de Lambert-Eaton / Études de suivi / Maladies de la jonction neuromusculaire / Membres / Oeil / Poumon / Tumeurs du poumon / Anticorps / Bouche Type d'étude: Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Humans / Male langue: En Texte intégral: Journal of Clinical Neurology Année: 2012 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Canaux calciques / Syndrome myasthénique de Lambert-Eaton / Études de suivi / Maladies de la jonction neuromusculaire / Membres / Oeil / Poumon / Tumeurs du poumon / Anticorps / Bouche Type d'étude: Observational_studies / Prognostic_studies / Risk_factors_studies Limites du sujet: Humans / Male langue: En Texte intégral: Journal of Clinical Neurology Année: 2012 Type: Article