Casein kinase 2 is a critical determinant of the balance of Th17 and Treg cell differentiation
Experimental & Molecular Medicine
;
: e375-2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-127718
ABSTRACT
Th17 cells promote inflammatory reactions, whereas regulatory T (Treg) cells inhibit them. Thus, the Th17/Treg cell balance is critically important in inflammatory diseases. However, the molecular mechanisms underlying this balance are unclear. Here, we demonstrate that casein kinase 2 (CK2) is a critical determinant of the Th17/Treg cell balance. Both the inhibition of CK2 with a specific pharmacological inhibitor, CX-4945, and its small hairpin RNA (shRNA)-mediated knockdown suppressed Th17 cell differentiation but reciprocally induced Treg cell differentiation in vitro. Moreover, CX-4945 ameliorated the symptoms of experimental autoimmune encephalomyelitis and reduced Th17 cell infiltration into the central nervous system. Mechanistically, CX-4945 inhibited the IL-6/STAT3 and Akt/mTOR signaling pathways. Thus, CK2 has a crucial role in regulating the Th17/Treg balance.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Techniques in vitro
/
Caséines
/
Système nerveux central
/
Lymphocytes T régulateurs
/
Petit ARN interférent
/
Casein Kinases
/
Casein Kinase II
/
Encéphalomyélite auto-immune expérimentale
/
Cellules Th17
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2017
Type:
Article
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