Inhibition of IgE-mediated anaphylactic reaction by Mentha arvensis in rats / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 601-608, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-12806
ABSTRACT
BACKGROUND:
It has been reported that Mentha arvensis water extract (MAWE) inhibited systemic anaphylaxis and histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. OBJECTIVE ANDMETHOD:
This study was undertaken to determine the inhibitory effects of immunoglobulin E (IgE)-mediated anaphylactic reaction by MAWE. This paper deals with an evaluation of the effect of MAWE on the anti-dinitrophenyl (DNP) IgE antibody induced anaphylactic reaction in rats. We also investigated the influence of MAWE on anti-DNP IgE antibody-induced tumor necrosis factor-alpha (TNF-alpha) production.RESULTS:
MAWE inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intrap- eritoneally, and orally administered. MAWE dose-dependently inhibited histamine release from RPMC activated by anti-DNP IgE antibody. Moreover, MAWE had an inhibitory effect on anti-DNP IgE antibody induced TNF-alphaproduction from RPMC.CONCLUSION:
These results suggest that MAWE inhibits the IgE-mediated anaphylactic reaction in rats.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Immunoglobuline E
/
Immunoglobulines
/
Anaphylaxie cutanée passive
/
Eau
/
Facteur de nécrose tumorale alpha
/
Mentha
/
Libération d'histamine
/
Anaphylaxie
/
Mastocytes
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Journal of Asthma, Allergy and Clinical Immunology
Année:
2000
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS