A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense
Diabetes & Metabolism Journal
;
: 106-112, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-128752
ABSTRACT
A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in diabetic complications, especially beta-cell dysfunction and failure. Under physiological conditions, reactive oxygen species serve as second messengers that facilitate signal transduction and gene expression in pancreatic beta-cells. However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and beta-cell death due to a lack of antioxidant defense systems. Taking into account the vulnerability of islets to oxidative damage, induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed as a way to protect beta-cells against diabetic insults. Here, we consider recent insights into how the redox response becomes deregulated under diabetic conditions, as well as the therapeutic benefits of antioxidants, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with beta-cell failure.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxydoréduction
/
Superoxide dismutase
/
Systèmes de seconds messagers
/
Transduction du signal
/
Expression des gènes
/
Choristome
/
Espèces réactives de l'oxygène
/
Stress oxydatif
/
Espèces réactives de l'azote
/
Complications du diabète
Type d'étude:
Revues systématiques évaluées
langue:
Anglais
Texte intégral:
Diabetes & Metabolism Journal
Année:
2013
Type:
Article
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