A Case of Coumarin-Induced Skin Necrosis / 대한피부과학회지

ABSTRACT

Coumarin-induced skin necrosis is a rare complication of oral administration of coumarin derivatives. Clinically, the lesions begin with well-defined purpuric patches and progress to bullae and necrosis on the trunk, buttock or female breast. Histopathologic findings show a fibrinoid degeneration or thrombus formation in the dermal blood vessels with occasional vessel rupture and hemorrhage. We report a 77-year-old man who suffered from a typical necrotic patch on his right buttock developing during the course of coumarin therapy. Our case was diagnosed as coumarin-induced skin necrosis, based on the characteristic clinical course and histopathologic findings.