The cardiovascular effects of midazolam co-induction to propofol for induction in aged patients / 대한마취과학회지
Korean Journal of Anesthesiology
; : 536-542, 2012.
Article
de En
| WPRIM
| ID: wpr-130233
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND: The aim of this study was to investigate whether a small dose of midazolam and lessening the propofol dosage could prevent cardiovascular change at tracheal intubation for induction in aged patients. METHODS: Eighty patients over 65 years (ASA physical status 1, 2) scheduled for elective surgery received general anesthesia with remifentanil and propofol or midazolam. Patients in group P (n = 40) were induced with 0.9% NaCl 0.03 ml/kg, propofol 1. 2 mg/kg and remifentanil. Patients in group MP (n = 40) were induced with midazolam 0.03 mg/kg, propofol 0.8 mg/kg and remifentanil. The time taken to reach loss of consciousness (LOC) and the value of bispectral index score (BIS) at LOC were recorded. After LOC, 0.8 mg/kg of rocuronium was given and tracheal intubation was performed. The mean blood pressure (MBP) and heart rate (HR) were recorded before induction as the base value, before intubation, immediately post-intubation and 3 minutes after intubation. RESULTS: Compared with the base values, MBP at before intubation and 3 minutes after intubation was significantly decreased in group P and group MP (P < 0.05). Compared with group P, the decrease of MBP was significantly less at before intubation, immediately after intubation and 3 minutes after intubation in group MP (P < 0.05). The time taken to reach LOC was significantly decreased in group MP compared with that in group P (P < 0.05). There were no significant differences of HR at any time between the two groups. CONCLUSIONS: Co-induction with midazolam and propofol could prevent a marked BP decrease at tracheal intubation for induction in aged patients.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pipéridines
/
Perte de conscience
/
Pression sanguine
/
Midazolam
/
Système cardiovasculaire
/
Propofol
/
Synergie des médicaments
/
Rythme cardiaque
/
Androstanols
/
Intubation
Limites du sujet:
Aged
/
Humans
langue:
En
Texte intégral:
Korean Journal of Anesthesiology
Année:
2012
Type:
Article