Risk factors for recurrence amongst high intermediate risk patients with endometrioid adenocarcinoma / 부인종양
Journal of Gynecologic Oncology
;
: 257-264, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-131056
ABSTRACT
OBJECTIVE:
To determine risk factors associated with recurrence in patients with high intermediate risk (HIR) endometrioid adenocarcinoma.METHODS:
A retrospective analysis of patients with HIR endometrioid adenocarcinoma who underwent hysterectomy, bilateral salpingo-oophorectomy, with or without pelvic/para-aortic lymphadenectomy at the University of Pennsylvania between 1990 and 2009 was performed.RESULTS:
A total of 103 women with HIR endometrial cancer were identified. Multivariable analysis revealed that > or =2/3 myometrial invasion (HR, 4.79; p=0.010) and grade 3 disease (HR, 3.04; p=0.045) were independently predictive of distant metastases. The 5-year distant metastases free survival (DMFS) for patients with neither or one of these risk factors was 89%, and the 5-year DMFS for patients with both risk factors was 48% (p<0.001).CONCLUSION:
Patients with both grade 3 disease and deep third myometrial invasion have a high risk of distant metastases. Identifying these patients may be important in rationally selecting patients for systemic therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
Pennsylvanie
/
Études rétrospectives
/
Facteurs de risque
/
Tumeurs de l'endomètre
/
Carcinome endométrioïde
/
Hystérectomie
/
Lymphadénectomie
/
Métastase tumorale
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
Pays comme sujet:
Amérique du Nord
langue:
Anglais
Texte intégral:
Journal of Gynecologic Oncology
Année:
2012
Type:
Article
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