How low is low enough? Evaluation of various risk-assessment models for lymph node metastasis in endometrial cancer: a Korean multicenter study / 부인종양
Journal of Gynecologic Oncology
;
: 251-256, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-131058
ABSTRACT
OBJECTIVE:
The aim of this study was to identify a standard for the evaluation of future models for prediction of lymph node metastasis in endometrial cancer through estimation of performance of well-known surgicopathological models.METHODS:
Using the medical records of 947 patients with endometrial cancer who underwent surgical management with lymphadenectomy, we retrospectively assessed the predictive performances of nodal metastasis of currently available models.RESULTS:
We evaluated three models included 1) a model modified from the Gynecologic Oncology Group (GOG) pilot study; 2) one from the GOG-33 data; and 3) one from Mayo Clinic data. The three models showed similar negative predictive values ranging from 97.1% to 97.4%. Using Bayes' theorem, this can be translated into 2% of negative post-test probability when 10% of prevalence of lymph node metastasis was assumed. In addition, although the negative predictive value was similar among these models, the proportion that was classified as low-risk was significantly different between the studies (56.4%, 44.8%, and 30.5%, respectively; p<0.001).CONCLUSION:
The current study suggests that a false negativity of 2% or less should be a goal for determining clinical usefulness of preoperative or intraoperative prediction models for low-risk of nodal metastasis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Dossiers médicaux
/
Prévalence
/
Études rétrospectives
/
Sensibilité et spécificité
/
Tumeurs de l'endomètre
/
Lymphadénectomie
/
Noeuds lymphatiques
/
Métastase tumorale
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Journal of Gynecologic Oncology
Année:
2012
Type:
Article
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