Human Bocavirus in Patients with Respiratory Tract Infection / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 179-184, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-131131
ABSTRACT
BACKGROUND:
Human bocavirus (HBoV) is a newly identified viral pathogen, and its clinical epidemiology and significance in respiratory infections have not yet been completely elucidated. We investigated the prevalence of HBoV infection and the association between viral (HBoV) load and clinical features of the infection in patients of all age-groups.METHODS:
Nasopharyngeal aspirates from patients with symptoms of respiratory infection were tested for presence of HBoV by using real-time polymerase chain reaction. HBoV-positive patients were categorized into low- and high-viral-load groups using 1.0x10(6) copies/mL as the threshold value of viral load.RESULTS:
Detection rate of HBoV was 4.8% (N=93) in a total of 1,926 samples with peak incidence of infection being observed in patients aged 6-12 months. HBoV infection was more frequently observed in young children, especially, in children aged less than 5 yr, and the HBoV load decreased with increase in age. HBoV was codetected with other respiratory viruses in 17 (18.3%) of the 93 HBoV-positive patients and 15 patients (88.2%) belonged to the low-viral-load group. Patients infected with HBoV alone showed a higher viral load than those patients in whom HBoV was codetected with other respiratory viruses (median load, 3.78x10(5) copies/mL vs. 1.94x10(4) copies/mL, P=0.014). Higher pulse rate (P=0.007) and respiratory rate (P=0.021) were observed in patients with a high-viral-load.CONCLUSIONS:
Our results suggest that HBoV may be the causative agent of respiratory infection in the high-viral-load group.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Infections de l'appareil respiratoire
/
ADN viral
/
Partie nasale du pharynx
/
Réaction de polymérisation en chaîne
/
Prévalence
/
Infections à Parvoviridae
/
Charge virale
/
Bocavirus humain
Type d'étude:
Étude de prévalence
/
Étude pronostique
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Anglais
Texte intégral:
The Korean Journal of Laboratory Medicine
Année:
2011
Type:
Article
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