Role of Salvia miltiorrhiza for Modulation of Th2-derived Cytokines in the Resolution of Inflammation
Immune Network
;
: 288-298, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-131305
ABSTRACT
BACKGROUND:
Salvia miltiorrhiza (SM) has been used to treat inflammatory diseases including edema and arthritis; however, the anti-inflammatory mechanism of SM action remains unresolved.METHODS:
The effects of an ethanol extract of SM (ESM) on pro-inflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, and NO, on anti-inflammatory cytokines including IL-4, IL-10, TGF-beta, and IL-1Ra have been studied in an attempt to elucidate the anti-inflammatory mechanism in murine macrophages.RESULTS:
ESM inhibited the production of pro-inflammatory cytokines via down-regulation of gene and protein expression whereas it increased the anti-inflammatory cytokines. Furthermore, ESM inhibited the expression of the chemokines, RANTES and CX3CL1, as well as of inflammatory mediators such as TLR-4 and 11beta-HSD1.CONCLUSION:
These results indicated that the regulatory effects of ESM may be mediated though the suppression of pro-inflammatory cytokines as well as the induction of anti-inflammatory cytokines. Consequently, we speculate that ESM has therapeutic potential for inflammation-associated disorders.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Régulation négative
/
Cytokines
/
Facteur de croissance transformant bêta
/
Interleukine-4
/
Interleukine-6
/
Facteur de nécrose tumorale alpha
/
Interleukine-10
/
Chimiokine CCL5
/
Chimiokines
/
Salvia
langue:
Anglais
Texte intégral:
Immune Network
Année:
2011
Type:
Article
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