Diabetic Ketoacidosis in a Patient with Acromegaly / 대한내분비학회지
Journal of Korean Society of Endocrinology
;
: 393-398, 2004.
Article
Dans Coréen
| WPRIM
| ID: wpr-131913
ABSTRACT
Acromegaly is a chronic, debilitating condition caused by excessive secretion of growth hormone (GH). Impaired glucose tolerance is present in about 20-40% of acromegaly, with diabetes mellitus developing in about 10~15% of patients, but diabetic ketoacidosis is a rare association. Herein is reported a case of diabetic ketoacidosis in a 33 year-old female, with a 4 year history of typical acromegaly features. She presented with severe hyperglycemia and ketoacidosis, but with no other cause for this metabolic derangement. She had elevated plasma GH (50 ng/mL) and IGF-1 (1533 ng/mL) levels, and a pituitary macroadenoma. About 200 units of insulin per day were required for her glycemic control. However, the serum IGF-1 level and daily insulin requirement were significantly tapered after a transsphenoidal adenomectomy and long acting somatostatin analogue treatment. There was a good correlation with the daily insulin requirement and plasma IGF-1 level. This case demonstrates that severe GH excess can cause diabetic ketoacidosis, and that its successful treatment improves glucose metabolism.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Acromégalie
/
Insulinorésistance
/
Facteur de croissance IGF-I
/
Somatostatine
/
Hormone de croissance
/
Acidocétose diabétique
/
Diabète
/
Glucose
/
Hyperglycémie
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Journal of Korean Society of Endocrinology
Année:
2004
Type:
Article
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